Lactation At least one particular death was noted in the nursing toddler who was subjected to high amounts of morphine in breast milk because the mom was an extremely-swift metabolizer of codeine.
you should know that this medication could make you drowsy. Usually do not push a car or operate equipment until finally you understand how this medication impacts you.
Promethazine is undoubtedly an antihistamine. It works by protecting against the effects of a compound termed histamine, which is produced by the human body.
A healthcare Qualified need to be consulted ahead of using any drug, switching any diet regime or commencing or discontinuing any training course of therapy.
The concomitant use of Promethazine with Codeine Oral Option with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may possibly end in a rise in codeine plasma concentrations as well as a minimize in active metabolite morphine plasma concentration which could lead to an analgesic efficacy reduction or signs or symptoms of opioid withdrawal.
Prior to taking this medication, explain to your physician or pharmacist if you are allergic to promethazine or to dextromethorphan; or to almost every other phenothiazines (including prochlorperazine); or if you have another allergy symptoms.
Avoid the usage of Promethazine with Codeine Oral Resolution in clients getting muscle relaxants. If concomitant use is essential, watch clients for signs of respiratory depression That could be greater than if not expected.
Use with warning in sufferers with underlying intestinal motility Diseases. The codeine in Promethazine with Codeine Oral Answer may perhaps induce spasm in the sphincter of Oddi, leading to an increase in biliary tract tension. Opioids may lead to boosts in serum amylase [seeWARNINGS AND Safety measures (5.21)]. Check individuals with biliary tract disorder, which includes acute pancreatitis for worsening indications. Administration of promethazine has long been associated with reported cholestatic jaundice.
This medicine must also include a Medication Guide. Browse and stick to these Guidelines very carefully. Read it yet again each time you refill your prescription in the event that There's new data. Ask your doctor if you have any questions.
The concomitant usage of codeine with other identified sedatives, like Alcoholic beverages or benzodiazepines, can appreciably improve the threat of adverse and possibly hazardous consequences. Naloxone availability might help as a certain antidote to reverse significant opioid overdose or CNS despair, even when they are secondary to concomitant use with other CNS depressing brokers.
Folks taking any opioid medication Have got a risk of overdose if they do not keep on with the prescribed dosage. Signs and symptoms of overdose consist of:
program to avoid needless or extended exposure to daylight and to Promethazine codeine syrup don protecting garments, sun shades, and sunscreen. Promethazine may make the skin sensitive to sunlight.
The moment the triage nurse has admitted a codeine overdose, the crisis Section clinician is responsible for coordinating the care, which may include things like any variety of the subsequent:
Codeine wasn't mutagenic during the in vitro bacterial reverse mutation assay or clastogenic in the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.